【摘 要】
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Objective: To observe the effects of Compound Ze Bei Granules (复方浙贝颗粒,CZBG) combined with chemotherapy on surface markers of Leukemia Stem Cell (LSC) in the bone marrow of patients with acute myeloid
【出 处】
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中华中医药学会第二届岐黄论坛—血液病中医药防治分论坛
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Objective: To observe the effects of Compound Ze Bei Granules (复方浙贝颗粒,CZBG) combined with chemotherapy on surface markers of Leukemia Stem Cell (LSC) in the bone marrow of patients with acute myeloid leukemia (AML).Methods: 78 patients with AML received bone marrow aspiration and the percentaaes of CD34+CD123+ cells and CD33+CD123+ cells were tested using flow cytometry method.A total of 24 refractory or relapsed AML patients were enrolled and treated with one cycle of standard chemotherapy combined with CZBG.Bone marrow samples were obtained before and after treatment, and the percentages of CD34+CD123+ cells and CD33+CD123+ cells were examined by flow cytometry.Results: ①Compared to refractory or relapsed acute myeloid leukemia patients, patients achieved remission had a significant lower percentage of CD34+CD123+ cells (P<0.01) and CD33+CD123+ cells (P<0.01), indicating that controlling the LSC percentage may be important for patients with AML to achieve sustainable remission.②Compared to those before treatment, the expression levels of CD34+CD123+ were significantly decreased after CZBG combined with chemotherapy treatment (P<0.01).③The percentages of CD34+CD123+ cells and CD33+CD123+ cells in patients achieving complete remission after CZBG combined with chemotherapy treatment were both significantly lower than those in the non-remission group (P<0.01).Conclusion: It demonstrated that CZBG combining chemotherapy could reduce the percentages of CD34+CD123+ and CD33+CD123+ leukemia stem cells, which might improve the clinical efficacy of refractory or relapsed AML.
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