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Background,Motivation and Objective As a result of the Warburg effect,dysregulated cellular pH is considered an emerging hallmark of cancer.Thus,The ability to noninvasively probe acidity at a cellular level could prove valuable in the early detection of cancer and sensing of cellular dynamics(e.g.,endocytosis) given that cancer cells are known to have a significantly higher intracellular than extracellular pH.To this end,we have developed a biocompatible pH-sensitive dye that is able to noninvasively measure cellular acidity through ratiometric analysis of multi-wavelength NIR photoacoustic(PA) imaging data.We demonstrate in vitro feasibility of ratiometric PA imaging of acidic pH of this novel liposomeencapsulated dye.