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  5. Ratiometric Photoacoustic Imaging of Acidic pH

Ratiometric Photoacoustic Imaging of Acidic pH

来源 :2015两岸超声技术与医学研讨会 | 被引量 : 0次 | 上传用户：emslwh
【摘 要】
：
Background,Motivation and Objective As a result of the Warburg effect,dysregulated cellular pH is considered an emerging hallmark of cancer.Thus,The ability to noninvasively probe acidity at a cellula
【作 者】
：
Richard Bouchard Samit Guha Trevor Mitcham Gillian Shaw Bradley Smith 
【机 构】
：
Imaging Physics,University of Texas MD Anderson Cancer Center,USA
【出 处】
：
2015两岸超声技术与医学研讨会
【发表日期】
：
2015年5期
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Background,Motivation and Objective As a result of the Warburg effect,dysregulated cellular pH is considered an emerging hallmark of cancer.Thus,The ability to noninvasively probe acidity at a cellular level could prove valuable in the early detection of cancer and sensing of cellular dynamics(e.g.,endocytosis) given that cancer cells are known to have a significantly higher intracellular than extracellular pH.To this end,we have developed a biocompatible pH-sensitive dye that is able to noninvasively measure cellular acidity through ratiometric analysis of multi-wavelength NIR photoacoustic(PA) imaging data.We demonstrate in vitro feasibility of ratiometric PA imaging of acidic pH of this novel liposomeencapsulated dye.
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