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So far biomarker discovery is not as fruitful as we would like to see.Is blood the best place to look for biomarkers? For all the cells to survive and function,blood is supposed to be homeostatic.It tends to minimize any changes introduced into it.Those changes are what we are looking for as biomarkers.We are playing hide-and seek with blood.That is why it is hard to find a biomarker.Unlike blood,urine is supposed to be dumped as waste.