【摘 要】
：
Previous studies have demonstrated the efficacy of electroacupuncture at ST36 for patients with gastrointestinal motility disorders.While several lines of evidence suggest that the effect may involve
【机 构】
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China Acadeny of Chinese Medical Sciences Institute of Acupuncture and Moxibustion,16 Nanxiaojie,Don
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Previous studies have demonstrated the efficacy of electroacupuncture at ST36 for patients with gastrointestinal motility disorders.While several lines of evidence suggest that the effect may involve vagal reflex,the precise molecular mechanism underlying this process still remains unclear.Here we report that the intragastric pressure increase induced by low frequency electric stimulation at ST36 was blocked by AP-5, an antagonist of NMDA receptors (NMDARs).Indeed, stimulating ST36 enhanced NMDAR-mediated, but not AMPA receptor (AMPAR)-mediated synaptic transmission in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV).We also identified that suppression of presynaptic μ-opioid receptors may contribute to up-regulation of NMDAR-mediated synaptic transmission induced by electroacupuncture at ST36.Furthermore, we determined that the NR2A-containing NMDARs are essential for NMDAR-mediated enhancement of gastric motility caused by stimulating ST36.Taken together, our results reveal an important role of NMDA receptors in mediating enhancement of gastric motility induced by stimulating ST36.
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