Enteroviruses,belonging to the genus of Enterovirus in the family Picomaviridae,are responsible for a variety of human and animal diseases,ranging from polio,through acute respiratory illnesses to hand-foot-and-mouth disease (HFMD) and the common cold.Am ong human enteroviruses,poliovirus and EV71 can cause severe neurological diseases,res ulting in millions of infections and thousands of deaths in the past five years.At present,no effective therapies are available.