Due to their excellent photophysical properties, BODIPY dyes are now regarded as valuable fluorescent scaffolds for designing labelling reagents, optical sensors and probes suitable for various bio-analytical applications.1,2 In order to obtain suitable solubility in water or in aq.buffer solution, the site-specific introduction of some hydrophilic moieties (positively-or negatively-charged groups such as ammoniums, carboxylates, phosphonates or sulfonates, PEG-type chains and biopolymers) into the poly-aromatic fluorescent core are the conventional routes utilized,3 Among the various synthetic strategies, we reported herein a new pathway to introduce the carboxylate group into a tripod BODIPY fluorescent structure via a hydrogenolysis of benzylester (Scheme.l).