【摘 要】
：
The globus pallidus plays a significant role in motor control under both health and pathological states.Recent studies have revealed that HCN channels occupy a critical position in globus pallidus pac
【机 构】
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Department of Physiology,Qingdao University,Qingdao,China
【出 处】
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International Conference for Physiological Sciences 2012(201
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The globus pallidus plays a significant role in motor control under both health and pathological states.Recent studies have revealed that HCN channels occupy a critical position in globus pallidus pacemaking activity.Morphological studies have shown the expression of HCN channel in the globus pallidus.To investigate the in vivo effects of HCN channels in the globus pallidus, extracellular recordings were performed in the present study.In normal rats, micro-pressure ejection of ZD7288 (0.05 mM), the selective HCN channel antagonist, decreased the firing rate by 59.6% in 18 out of the 49 pallidal neurons.Interesting, in another 22 out of the 49 pallidal neurons,ZD7288 increased the firing rate by 154.7%.In rats with STN lesions, ZD7288 decreased the firing rate by 51.8%in 29 out of 57 pallidal neurons, and increased by 202.7% in other 24 neurons.The electrophysiological results suggest that HCN channels may modulate the firing properties ofpallidal neurons by different pathways.
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