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Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) is one of the important enzymes involved in the folate metabolic pathway and a common polymorphism (66A > G) has been associated with acute lymphoblastic leukemia (ALL) but results were controversial.To better clarify the effect of MTRR 66A >G on the risk of ALL,a meta-analysis was performed.Online major databases were searched to identify case-control studies regarding MTRR 66A >G polymorphism and ALL.The results suggested that the A allelic frequency was associated with a increased ALL risk in Caucasian populations(OR =1.16; 95%CI =1.05-1.28) and in pediatric group(OR =1.12; 95%CI =1.02-1.24).In conclusion,our study indicates that MTRR A allele increased the susceptibility to ALL in Caucasians and children.