本文用小鼠扭体法、热板法、甲醛法等三种致痛模型测试并证实眼镜蛇毒有镇痛作用,存在良好的量效关系,作用较吗啡持久。小鼠连续五天给药(0.4mg/kg ip),镇痛作用不产生耐受,与吗啡亦无交叉耐受性,其镇痛作用不被纳络酮拮抗。皮下注射0.4mg/kg对大鼠足跖角叉菜或鲜蛋清炎症模型有明显消肿作用。本文提示眼镜蛇毒有镇痛和消炎作用,其镇痛机制可能与吗啡不同,属另一类非麻醉性镇痛药。 In this paper, writhing mouse method, hot plate method, formaldehyde method and other three pain model test and confirm cobra venom analgesic effect, there is a good dose-effect relationship, the role of long-lasting morphine. Mice were administered for five consecutive days (0.4 mg / kg ip), with no analgesic effects and no cross-tolerance with morphine, and their analgesic effects were not antagonized by naloxone. Subcutaneous injection of 0.4mg / kg on rat paw carotid or egg white inflammation model significantly swelling. This paper suggests cobra venom has analgesic and anti-inflammatory effects, the analgesic mechanism may be different with morphine, is another type of non-narcotic analgesics.