Trifluoromethylated compounds are of particular interest in the field of pharmaceuticals,and agrochemicals due to the unique characteristics of the trifluoromethyl group(-CF3),such as high electronegativity and hydrophobicity.Hence,it has been of great synthetic interest to develop an efficient method for incorporation of CF3 into organic molecules.To the best of our knowledge,the reported methods for synthesis of CF3-containing compounds can be divided two-type reactions:the reaction of trifluoromethylated electrophilic agents with nucleophiles and the coupling of trifluoromethylated nucleophilic agents with electrophiles.Recently,transition-metal-catalyzed oxidative cross-coupling of two nucleophiles has captured growing attention from the synthetic organic chemistry community.This concept was first extended to organofluorine chemistry by our group.Since we original proposed the oxidative trifluoromethylation in 2010,the oxidaive trifluoromethylation provides a protocol for a novel,efficient and versatile route to constract C(sp,sp2,sp3)-CF3 bonds.1 Very recently,we have accomplished silver-mediated oxidative trifluoromethylation of phenols and alcohols to aryl(alkyl) trifluoromethyl ethers.