2. 您的位置
3. 首页
4. 会议论文
5. 压力超负荷或非肺动脉高压大鼠直接死因

压力超负荷或非肺动脉高压大鼠直接死因

来源 :第17届中国南方国际心血管病学术会议 | 被引量 : 0次 | 上传用户：haidastudent

【摘 要】

：

目的 探究MCT-induced-PAH大鼠的死亡原因及可能的应对策略;方法 雄性SD大鼠,随机分为对照组20只(A),模型组60只(B),死亡组(C,死亡大鼠),腹腔注射野百合碱50mg/kg诱导PAH模型,观察记录动物习性改变,8周后计算死亡率,测量体重、右室压力,右室肥厚指数,肺小微动脉管壁肥厚指数及炎症浸润.用万方、维普、知网、百度学术数据库,设定检索词和纳入和排除标准,对模型分布、死亡率

【作 者】

：

杨东鹏 董文鹏 杨永超 王晓武 

【机 构】

：

广州军区广州总医院心脏外科;广州中医药大学 广州军区广州总医院心脏外科

【出 处】

：

第17届中国南方国际心血管病学术会议

【发表日期】

：

2015年9期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

目的 探究MCT-induced-PAH大鼠的死亡原因及可能的应对策略;方法 雄性SD大鼠,随机分为对照组20只(A),模型组60只(B),死亡组(C,死亡大鼠),腹腔注射野百合碱50mg/kg诱导PAH模型,观察记录动物习性改变,8周后计算死亡率,测量体重、右室压力,右室肥厚指数,肺小微动脉管壁肥厚指数及炎症浸润.用万方、维普、知网、百度学术数据库,设定检索词和纳入和排除标准,对模型分布、死亡率、死因等进行分析.

其他文献

The effect of high glucose on the generation of ROS and expression of Nrf2 of human umbilical vein e

Objective To investigate the effect of high glucose on the generation of ROS and the expression of Nrf2 of human umbilical vein endothelial cells (HUVEC).Methods: Human umbilical vein endothelial cell

会议

重组ACE2对高血压小鼠海马BDNF-MAPK信号的影响

目的 脑肾素-血管紧张素系统(RAS)及其新成员血管紧张素转换酶2(ACE2)是机体内调控血压水平和神经内分泌功能的最重要机制之一.大脑中的RAS系统通过其主要效应物质血管紧张素Ⅱ(Ang Ⅱ)参与脑海马脑源性神经营养因子(BDNF)信号调控过程.本研究旨在探讨高血压小鼠脑海马组织中BDNF与丝裂原活化蛋白激酶(MAPKs)信号改变及重组ACE2干预后对该信号通路的影响.

会议

TLR4/NF-κB signal mediates Ox-LDL-induced calcification of human vascular smooth muscle cells

Objective Vascular calcification is a major feature of advanced atherosclerosis and highly associated with cardiovas cular diseases.Toll like receptor 4 (TLR4) is highly expressed in atherosclerotic l

会议

Controlled delivery of rAAV9-cyclinA2 with recruited stem cell using fibrin glue improves cardiac fu

Objective Cyclin-A2, which normally disappears after birth, is a key regulator of mammalian cell cycle.Fibrin glue is a common biological scaffold and wall support in ischemic myocardium.This study is

会议

Ciglitazone ameliorates ox-LDL-induced endothelial dysfunction by modulating eNOS activity via PPARγ

Aim Thiazolidinediones (TZDs), the antidiabetic agents such as ciglitazone, has been proved to be effective in limiting atherosclerotic events.However, its role in endothelial dysfunction (ED) remains

会议

5-ALA/SFC-induced autophagy mediated by HO-1 signaling in HL-1 cardiomyocytes with apoptosis inhibit

Objective Hypoxia causes cardiac disease via oxidative stress, mitochondrial dysfunction or protein misfolding and aggregation.Autophagy plays pathogenetic roles in eliminating damaged protein and mai

会议

The effect of different low temperature on Bax and Bcl2 protein in rats with spinal cord ischemia re

Objective To evaluate the expression changes of Bax and Bcl2 after spinal cord ischemia reperfusion injury (SCII) and exposition in the hypothermia during the operation in the rats.Methods 60 Rats wer

会议

整合素连接激酶通过抑制缝隙连接蛋白43重塑改善大鼠离体心脏缺血再灌注室性心律失常

目的 研究整合素连接激酶(ILK)在大鼠离体心脏缺血再灌注室性心律失常中的作用及机制.方法 使用8-10周龄(200～230g)的雄性SD大鼠,采用Langendorff离体心脏灌注系统,结扎冠脉左前降支缺血30分钟,再灌注30分钟,建立缺血再灌注心律失常模型,予ILK活性调节剂预处理,监测大鼠缺血再灌注室性心律失常的变化,通过Western blot及免疫荧光染色法分析缝隙连接蛋白43(Cx43

会议

Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hyper

Aims Drag-reducing polymers (DRPs) are blood-soluble macromolecules that can increase blood flow and reduce vascular resistance.The purpose of the present study is to observe the effect of DRPs on mon

会议

Lin28a protects against cardiac ischemia/reperfusion injury in diabetic mice through the insulin-PI3

Aims The insulin-PI3K-mTOR pathway exhibits a variety of cardiovascular activities including protection against I/R injury.Lin28aenhanced glucose uptake and insulin-sensitivity via insulin-PI3K-mTOR s

会议