【摘 要】
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Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective way of treating leukemia and other malignant diseases.However, disease recurrence is still the major cause of dea
【机 构】
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Institutes of Biology and Medical Science, Soochow University, Suzhou
【出 处】
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中国免疫学会第九届全国免疫学学术大会
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Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective way of treating leukemia and other malignant diseases.However, disease recurrence is still the major cause of death after HSCT.Previous studies showed that donor NK cell infusion could prevent disease recurrence possibly through killing residual leukemia cells.Whether donor NK cells expanded in vitro could have prolonged survival and killing capacity in vivo is the key for their antileukemia effects.Therefore, the strategy to better maintain donor NK cells anti-leukemia activity during in vitro expansion is critical for donor NK cell therapy.
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