【摘 要】
：
Cyclin G2是细胞周期和细胞增殖的负性调控因子，其表达受雌激素调节。有研究报道cyclin G2能够通过PPAR γ调节细胞成脂分化及脂滴形成，提示其可能参与细胞的成骨调控。我
【机 构】
：
中国医科大学医学基因组学教研室,沈阳110122
【出 处】
：
中国细胞生物学学会2015年全国学术大会
论文部分内容阅读
Cyclin G2是细胞周期和细胞增殖的负性调控因子，其表达受雌激素调节。有研究报道cyclin G2能够通过PPAR γ调节细胞成脂分化及脂滴形成，提示其可能参与细胞的成骨调控。我们在具有成骨分化能力的细胞中添加雌激素和成骨条件培养液诱导细胞成骨分化，发现细胞成骨功能上调伴随着cyclin G2表达下调，且雌激素能够增强上述作用。另外，应用绝经后骨质疏松小鼠模型模拟体内雌激素缺乏引起细胞成骨分化降低，发现模型组小鼠骨密度降低伴有骨中cyclin G2表达升高。
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