急性肺损伤(ALI)或急性呼吸窘迫综合征(ARDS)是临床常见急危重症。各种病因包括严重感染、创伤、休克、急性胰腺炎、肺炎等肺内或肺外因素均可导致ALI/ARDS,发病机制主要包括炎症反应、细胞凋亡、氧化应激和肺泡毛细血管膜的损害等,目前尚无特殊有效的治疗方法,临床上也无修复肺损伤的有效药物。促红细胞生成素(EPO)作为一种多功能的内源性调节因子对各种组织损伤有一定的细胞保护作用,尤其是肺组织〔1〕,成为治疗ALI/ARDS的研究热点,本文就EPO对ALI/ARDS的保护作用及相关研究机制进行综述 Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common clinical critically ill. A variety of causes, including severe infection, trauma, shock, acute pancreatitis, pneumonia and other pulmonary or extra-pulmonary factors can lead to ALI / ARDS, the pathogenesis mainly includes inflammation, apoptosis, oxidative stress and alveolar capillary membrane Damage and so on, there is no special and effective treatment, there is no clinically effective drug to repair lung injury. Erythropoietin (EPO) as a multifunctional endogenous regulatory factor on a variety of tissue damage have some cytoprotective effects, especially lung tissue [1], become the research focus of the treatment of ALI / ARDS, EPO The protective effect of ALI / ARDS and related research mechanisms are reviewed