【摘 要】
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Background, Motivation and Objective Monoclonal antibodies are used as therapeutic agents for the treatment of diseases including cancer. However, their therapeutic efficiency for solid tumors remains
【机 构】
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UMR Inserm U930, Université Fran(c)ois-Rabelais, TOURS, France
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Background, Motivation and Objective Monoclonal antibodies are used as therapeutic agents for the treatment of diseases including cancer. However, their therapeutic efficiency for solid tumors remains modest, likely due to a limited intratumoral distribution of these macromolecules after systemic administration. Sonoporation is an innovative approach using ultrasound and gas microbubbles leading to increased permeability of endothelial wall, thus facilitating the passage of molecules. The objective of this study is to optimize the bioavailability of a therapeutic antibody Cetuximab into the tumor after sonoporation.
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