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Objective:The aim of the present study was to quantify the effects and safety of oral treatment with low-molecular fish collagen hydrolysate on female facial skin.Methods :Thirty volunteers were randomized to divide into the testing group and the control group.The testing group was given 6 g low-molecular fish collagen hydrolysate daily for 30 days, and the food free of collagen hydrolysate was ingested by the control group.Questionnaires and Visia(@) complexion analysis system were used to assess before and afer the experiment.Body routine examination and blood biochemical indicator were also carried.Results :Questionnaires revealed that low-molecular fish collagen hydrolysate improved sleep and enhanced physical function (P＜0.05).Wrinkles, pores, evenness, porphynins, moisture and sebum were improved signficantly(P＜0.05)in the testing group.But there was no significant changes in the control group.All the Body routine examination and blood biochemical indicator of the subjects were normal.Conclusion :Low-molecular fish collagen hydrolysate was safe and had the benefit to the facial skin.