A non-fullerene solar cell(NF-SC)employs n-type organic semiconductor(small molecule or polymeric)as the non-fullerene acceptor(A),which is used to replace the fullerene one in organic solar cells.The non-fullerene acceptor is normally blended with polymer or small molecule donor(D),forming so-called bulk-heterojunction(BHJ)structure.The resulted BHJ blend acts as the photoactive layer to harvest the solar energy.In recent two years,the power conversion efficiency(PCE)of a state-of-the-art NF-SC has been fast raised,going from 4%to over 6%.The achievement of a PCE value up than 6%means that the NF-SC is potential to compete with the fullerene based counterparts.In this talk,I will show you the advance and challenges in this field.