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Purpose Toevaluatetheperformanceofvolumeperfusioncomputedtomography(VPCT)parametersinpreoperativepredicting theWorldHealthOrganization(WHO)classificationsandMasaokastagesofthymicepithelialtumors(TETs). Materials and MethodsThisstudywasapprovedbythelocalEthicsCommittee,andinformedconsentwaswaived.Thirtytwo patientsofTETsconfirmedbyhistopathologicalanalysisunderwentconventionalCTanda45-sVPCTscanofthetumorbulk beforeanytreatment.TheVPCTparameters(bloodvolume(BV),bloodflow(BF),meantransittime(MTT)andpermeability(PMB))werecomparedfordifferencesamonglow-riskthymomas(LRT,typesA,AB,andB1),high-riskthymomas(HRT,typesB2 andB3)andthymiccarcinomas(TC),alsobetweenearly(MasaokastageⅠandⅡ)andadvanced(MasaokastageⅢandIV)stage TETsbasedonone-wayANOVAandindependentsamplettest,respectively.Receiveroperatingcharacteristiccurve(ROC)were performedtodeterminethepotentialfordifferentiatingtheLRTfromHRTandTCbyvariousparameters. Results ThemeanBV,BFandPMBvalueinLRTweresignificanthigherthanthevaluefromHRTandTC(BV,14.46,7.90and5.67 ml/100ml;BF,86.11,51.01and59.05ml/100ml/min;andPMB,21.98,12.84and14.28ml/100ml/min,respectively,allP< 0.05),whiletherewerenosignificantdifferencebetweentheHRTandTC(P﹥0.05).TheMTTvalueinTCweresignificantlower thanthevaluefromLRTandHRT(P<0.05),andnosignificantdifferencewasfoundbetweentheLRTandHRT(P﹥0.05).In addition,themeanBV,BFandMTTvalueinearlystageweresignificantlyhigherthantheadvancedstages(BV,13.34and7.26 ml/100ml;BF,81.16and56.36ml/100ml/min;andMTT,12.36and9.79sec,respectively,allP<0.05).TheAUCandcutoffvalue, respectively,fordifferentiatingLRTfromHRTandTCforBV,BFandPMBwereasfollows:BV,0.900and11.32ml/100ml;BF, 0.796and58.82ml/100ml/min;andPMB,0.775and21.99ml/100ml/min,respectively,fordifferentiatingearlyfromadvanced TETs:BV,0.818and9.25ml/100ml;BF,0.717and74.09ml/100ml/min;andMTT,0.692and12.21sec,respectively. Conclusions TheVPCTcanbeusedtopredictthepathologicalclassificationandMasaokastagespreoperatively.