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In the present study,the degranulafion of mast cell and histamine release involved in scorpion Buthus martensi Karch (BmK) venom induced-pain behaviors and edema was investigated.It was found that the degranulation of mast cell in rat hindpaw skin could be triggered by BmK venom significantly.The chronic degranulation of mast cells treated with compound 48/80 relieved the spontaneous nociceptive responses,the primary thermal,bilateral mechanical hyperalgesia and the rat paw edema,as well as partially reduced c-Fos expression in superficial layers of bilateral spinal cord induced by BmK venom.In addition,individual peripheral administration of either 100 nmol chlorpheniramine,100 nmol pyrilamine (histamine H1 receptors antagonist) or 500 nmol cimetidine (H2 receptors antagonist) suppressed the spontaneous nociceptive responses,partially the primary thermal,bilateral mechanical hyperalgesia and rat paw edema induced by BmK venom.Thus,it was suggested that the peripheral cellular incidents of mast cell degranulation and histamine release were involved in scorpion BmK venom induced-inflammatory pain.