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Background To elucidate effect of dual antiplatelet therapy on platelet response in acute myocardial infarction patients with chronic kidney disease.Methods From September 2011 to June 2012, a total of 195 acute myocardial infarction patients undergoing drug eluting stem implanting were enrolled, among them, 133 cases with normal renal function, and 62 cases with chronic kidney disease (CKD).We examined platelet reactivity after clopidogrel 300 mg and aspirin 300 mg treatment for 24hours.High on treatment platelet reactivity (HPR) was defined as >55% for light transmission aggreometry.