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Research interests帕金森病的临床和病理特征1.Nigral DA neuron loss2.Striatal DA level decrease3.Lewy Body and protein aggregation4.Neuroinf lammation midbrainSleep disturbance is an early sign of PD Sleep disorders in PD patients Sleep and electromyographic activity in REM sleep in LRRK2 and idiopathic PD patients Sleep disorders in PD patients Sleep quality in Parkinsons disease