【摘 要】
：
Objective: Epidermal growth factor receptor (EGFR) mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) define specific molecular subsets of lung adenoc
【机 构】
：
Department of molecular pathology, the Affiliated Tumor Hospital of Zhengzhou University,Zhengzhou,
【出 处】
：
第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective: Epidermal growth factor receptor (EGFR) mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) define specific molecular subsets of lung adenocarcinoma with distinct clinical features.Our purpose is to analyze clinical features and prognostic value of EGFR gene mutations or EML4-ALK fusion gene in lung adenocarcinoma.Methods: EGFR gene mutations and EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients of China.The tumor markers level before the first treatment was measured by electrochemiluminescence immunoassay.
其他文献
目的:通过与传统开放手术的对比,探讨经皮微创椎弓根钉内固定融合术治疗腰椎退变性疾病的临床疗效.方法:回顾性分析2009年1月～2012年4月我院骨科收治的腰椎退变性疾病患者共87例,其中41例行Viper经皮椎弓根钉内固定+Pipeline通道下腰椎管减压、椎间盘切除、椎间融合术(经皮组),46例行开放椎弓根钉内固定、椎管减压椎间融合术(开放组).观察两组患者手术时间、术中透视次数、术中出血量及术
Comparing to late Phase Ⅱ/Ⅲ development, Early drug development (EDD) is a field of relative freedom to optimize the chances of success in the last step of registration.But Early drug development in E
Objective: Modified Response Evaluation Criteria In Solid Tumors (mRECIST), developed by the American Association for the Study of Liver Diseases (AASLD) criteria measure changes in arterialized hepat
目的:Ipilimumab(Ipi)是通过阻断细胞毒T淋巴细胞抗原-4来扩增抗肿瘤免疫应答的完全人源化单克隆抗体,获准用于治疗进展期黑色素瘤.本摘要将报告一项Ⅲ期试验的结果,该试验旨在对Ipi在高复发风险的Ⅲ期黑色素瘤患者手术切除后作为的辅助治疗进行评价.方法:本项随机、双盲试验的患者入选标准为:年龄≥18岁,接受Ⅲ期皮肤黑色素瘤(除外淋巴结转移≤1mm或转移过程中的肿瘤)完全切除术.951例患者
Objective:观察紫杉醇加顺铂(TP)方案与顺铂加氟尿嘧啶(PF)方案同步放化疗对局部晚期喉癌的疗效和毒副反应.Method:回顾分析47例局部晚期喉癌患者,分成紫杉醇加顺铂化疗同步放疗组(TP组,24例)和顺铂加氟尿嘧啶化疗同步放疗组(PF组,23例).TP组采用紫杉醇135mg/m2静点d1,+顺铂25mg/m2静点d1～3,28d为一周期,共4周期.PF组采用顺铂25mg/m2静点d1
目的:恶性卵巢甲状腺肿是一种罕见肿瘤,目前在其诊断与治疗方面尚未达成共识.本文报告一例国际罕见的恶性卵巢滤泡型甲状腺癌在行卵巢切除术17年后出现肺转移的病例,经妇产科、病理科、基本外科、核医学科等多学科协作制定治疗方案,获得临床完全缓解的诊治及随访过程.方法:38岁女性患者因"卵巢甲状腺肿"于17年前行"左侧卵巢切除术".2009年发现可疑肺转移,行肺结节穿刺活检及卵巢切除标本病理会诊后,诊断为恶
晚期口腔颌面-头颈鳞癌的治疗仍然是个巨大的挑战.尽管传统的手术、放疗及化疗近年来都取得了很大的进展,但晚期口腔颌面-头颈癌的预后仍然较差,分子靶向药物的兴起为此带来了希望.目前针对头颈癌的靶向治疗的靶点主要有表皮生长因子受体及血管内皮生长因子受体,前者的代表药物有西妥昔单抗及尼妥珠单抗,他们无论是单药治疗,还是与放化疗结合治疗,均表现出了良好的前景;后者的代表药物主要是贝伐单抗,也已经进行到临床Ⅲ
目的:探讨家族性非髓样甲状腺癌(familialnon-medullarythyroidcancer,FNMTC)的临床病理特征,以及3例及3例以上患者家系是否较2例患者家系的临床病理特征更具有侵袭性,3例或3例以上患者、同时累及两代的家系是否比其他家系更具有侵袭性.方法:收集北京协和医院2009年1月至2013年7月间诊治的家族性非髓样甲状腺癌27个家系、55例患者,回顾分析其临床病理资料,比较
Objective: We performed a meta-analysis of cohort studies to determine whether promoter methylation of death-associated protein kinase (DAPK) gene contribute to the pathogenesis of non-small cell lung
Objective: Lung cancer is an important and widespread disease that constitutes a major public health problem, but early detection of small cell lung cancer can significantly improve the survival rate