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Objective Neisseria gonorrhoeae(NG)is causative of gonorrhea,a sexually transmitted disease(STD)characterized by purulent inflammation of the mucous membranes of human genitourinary system.This study aimed to gain information on the antimicrobial susceptibility and molecular epidemiological typing of NG isolates in China in 2012.Methods A total of 244 NG isolates were recovered from patients with uncomplicated gonorrhea attending sexually transmitted disease(STD)clinics in three Chinese cities–Guangzhou,Nanjing,and Tianjin—in 2012.NG susceptibilities to penicillin and tetracycline were examined by detecting penicillinase-producing NG(PPNG)and high-level tetracycline-resistant NG(TRNG); and NG susceptibilitiesto ciprofloxacin,spectinomycin,ceftriaxone,and cefixime were determined using agar dilution method.NG isolateswere typed bymultiple-locus variable number tandem repeat analysis(MLVA).χ2tests,and univariate and multivariable analyses were also conducted.