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Aim:Mollugin,a kind of naphthohydroquinone,is the main and index component for controlling the quality of Rubia cordifolia L.Recently,several studies reported that mollugin possesses antitumor and anti-inflammatory activities.However,the mechanisms underlying these actions of mollugin have not yet been elucidated.In the present study,we investigaed the effect and the act mechanisms of mollugin on the inflammatory responses induced by lipopolysaccharide (LPS) in RAW264.7 macrophages.