Histone acetyltransferase PCAF is required for ATRA-induced granulocytic differentiation in APL cell

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In cancer,defective differentiation is one of characteristics and targeted for therapy.Compared to general therapeutic strategies with cytotoxic compounds in cancer treatment,the differentiation therapy is expected to be less toxicity.The treatment with all-trans retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is currently only clinically applied differentiation therapy.
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