【摘 要】
：
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe bleeding disorder that results from fetal platelet destruction caused by maternal anti-platelet antibodies during the pregnancy.FNAIT
【机 构】
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University of Toronto Canda
【出 处】
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BIT`s 1st International Congress of Gynaecology and Obstetri
论文部分内容阅读
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe bleeding disorder that results from fetal platelet destruction caused by maternal anti-platelet antibodies during the pregnancy.FNAIT is also linked with miscarriage.The major target antigens in FNAIT are the platelet GPⅢa (β3 integrin) and GPIbα.We established the first animal model of FNAIT with β3 integrin-deficient mice(Blood.2006;107: 2976-2983).We further demonstrated that neonatal Fc receptor (FcRn) is essential for the pathogenesis of the disease, and fetal FcRn is required for maternal IgG cross-placental transport (Blood.2010;116:3660-3668).Most recently, we developed a new FNAIT model with GPIbα-deficient mice, wefound thatthe maternal immune response to fetal GPIbmay cause previously unidentified, non-classical FNAIT (i.e.spontaneous miscarriage) (Journal of Clinical Investigation.2011;121:4537-47).Wefound that antibody-mediated immune suppression can be auseful prophylaxis(Transfusion.2012;52: 1446-57), and maternal IVIG administration and our newly developed anti-FcRn therapy may be efficient therapies to control this life-threatening disease.
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