【摘 要】
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Background:The objective of this study was to discover promising biomarkers for buccal squamous cell carcinoma(BSCC)patients arising in the background of oral submucous fibrosis(OSF)by using quantitat
【机 构】
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Xiangya Hospital,Changsha,Hunan,China
【出 处】
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第九次全国口腔颌面-头颈肿瘤学术研讨会
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Background:The objective of this study was to discover promising biomarkers for buccal squamous cell carcinoma(BSCC)patients arising in the background of oral submucous fibrosis(OSF)by using quantitative proteomics.Materials and Methods: BCSS,OSF,and normal buccal tissue(NBM)were collected for proteomics analysis.Proteins from each group were labelled with isobaric tags for relative and absolute quantitation(iTRAQ),then analyzed by LC-MS/MS.The evaluation of candidate biomarkers includes Western blotting and immunohistochemistry,then a clinical validation of promising biomarkers in a retrospectively study.
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