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5. Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic

Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户：lovelyhuanhuan

【摘 要】

：

　　The activity of the ribosome protein subunit 6 kinase 1 (S6K1) is stimulated by phosphorylation of Thr389 in the hydrophobic motif by mTORC1 and phosphoryla

【作 者】

：

王建船 钟琛 王放 瞿芳芳 丁建平 

【机 构】

：

中国科学院上海生命科学研究院,生物化学与细胞生物学研究所分子生物学国家重点实验室;中国科学院大学,北京100049中国科学院上海生命科学研究院,生物化学与细胞生物学研究所分子生物学国家重点实验室中国科

【出 处】

：

2013年第四届全国“跨学科蛋白质研究”学术讨论会

【发表日期】

：

2013年10期

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论文部分内容阅读

　　The activity of the ribosome protein subunit 6 kinase 1 (S6K1) is stimulated by phosphorylation of Thr389 in the hydrophobic motif by mTORC1 and phosphorylation of Thr229 in the activation loop by PDK1;however, the order of the two events is still ambiguous.

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