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Silver nanoparticles have received considerable interest as new "nanoantibiotics"with the potential to kill drug-resistant microorganisms.Recently,a class of new core-shell nanostructures,Pd@Ag nanosheets(Pd@Ag NSs),were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in vitro.In this study,we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal pathogens.Among these organisms,Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs,which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant isolates.