【摘 要】
：
For complex eukaryotes,it is a significant challenge to determine Which parts of the genome are transcribed then translated into proteins and when determini
【机 构】
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UniversityofNorthCarolinaUSA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
For complex eukaryotes,it is a significant challenge to determine Which parts of the genome are transcribed then translated into proteins and when determining how protein expression is regulated from a large population of gene transcripts may play a key role in gaining mechanistic understanding of disease progression.Proteogenomic mapping uses mass-spectrometry to analyze and identify proteins from biological samples in order to determine which genes and their exons are translated in a given biological sample.However,there are significant technical challenges in applying it to large genomes with complex multi-exon genes,including the accuracy ofprotein/peptide identification,large computation times,and effectively managing and visualizing the resulting data.
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