Induction of senescence in cancer cells by a G-quadruplex stabilizer BMVC4 is independent of its tel

来源 :第十五届亚太分子生物学网络组织年会 | 被引量 : 0次 | 上传用户:pgzwoaini1
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Telomerase is the enzyme responsible for extending G-strand telomeric DNA and represents a promising target for neoplasia therapeutic treatments.Inhibition of telomerase can be achieved by stabilization of G-quadruplex DNA structures. Here we characterized a novel compound,3,6-bis (4 -methyl-2-vinylpyrazinium) carbazole diiodine ( BMVC4). that stabilized G-quadruplex structure and inhibited telomerase activity in vitro.
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