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OBJECTIVE To investigate the effect of hydrogen-rich saline on platelet activation in hypertensive rats.METHODS The male Wistar rats were divided into control group, hypertension group, control + hydrogen-rich saline group and hypertension + hydrogen-rich saline group.Hypertension was induced by subcutaneous infusion with angiotensin Ⅱ 0.7 mg· kg-1 · d-1 for 2 weeks by osmotic mini-pumps in rats.