【摘 要】
：
Large cohort studies have revealed a close relationship between cognitive impairment and cardiovascular diseases, although the mechanism underlying this relationship remains incompletely understood.In
【出 处】
：
2015全国老年痴呆与认知障碍相关疾病学术大会
论文部分内容阅读
Large cohort studies have revealed a close relationship between cognitive impairment and cardiovascular diseases, although the mechanism underlying this relationship remains incompletely understood.In this study, using a transgenic (Tg) mouse model of cardiac-specific overexpression of microRNA-1-2 (miR-1-2), we observed that microRNA-1 (miR-1) levels were increased not only in the heart but also in the hippocampus and blood, whereas its levels did not change in the skeletal muscle of Tg mice compared with age-matched wild-type (WT) mice.Six-month-old Tg mice showed cognitive impairment compared with agematched WT mice, as assessed using the Morris Water Maze test.
其他文献
目的 托卡朋和恩他卡朋是新型帕金森病治疗药物。本研究旨在探讨二者对UGTs活性抑制作用,预测UGT1A1抑制引发的潜在药物-药物相互作用(DDI)。方法 以混合人肝微粒体(HLM)及重组表达UGTs作为酶源,选用4-甲基伞形酮(4-MU)、三氟拉嗪(TFP)、N-3-羧丙基-4-羟基-1,8-萘酰亚胺(NCHN)分别为UGTs酶的广谱探针底物,UGT1A4和UGT1A1的特异性探针底物,评估托卡朋
Pharmacological activities of some natural products diminish even disappear after purification.Here we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extrac
Pyrrolizidine alkaloids (PAs) are a kind ofhepatotoxic alkaloids, which widely exist in plants.Cytochrome P450 (CYP) 3A mediates metabolic activation of PAs, and the electrophilic products can cause c
Background: So far, no PDE4 inhibitors in Alzheimers disease has been approved for application in the clinic due to severe side effects such as nausea and vomiting.Objective: In this study, we investi
Aim: Emerging data have demonstrated that peroxisome proliferator-activated receptor δ (PPARδ) activation confers a potential neuroprotective role in some neurodegenerative diseases.However, whether P
目的 基于网络药理学,建立化合物的抗衰老活性预测模型,并以果蝇为模式生物验证其抗衰老作用.方法 (1)抗衰老活性预测模型的建立基于人类衰老基因资源数据库(Human Ageing Genomic Resources database,HAGR)查找衰老相关基因,运用STRING等数据库搜集衰老基因之间的相互作用数据,建立衰老相关的基因-基因相互作用网络,计算每个基因的自由度,获得衰老相关基因系数,
目的:中枢神经系统疾病(central nervous system diseases)发病率逐年增多,成为影响我国人口健康水平和生活质量的重大社会问题.目前中枢神经系统疾病的治疗及诊断药物存在的主要问题是血脑屏障(blood-brain barrier,BBB)通透性的问题:大部分治疗及诊断药物全身给药后难以透过BBB达到脑内有效治疗浓度,影响了药物的治疗及早期诊断效果.因此,本实验选用姜黄素前
目的：在前期工作基础上,利用Sig1受体基因敲除小鼠进一步确定Sig-1受体激动在改善脑缺血再灌注后小鼠学习记忆障碍中的作用,并且利用NMDA-2A(NR2A)受体拮抗剂,考察Sig-1受体如何调节BDNF的表达.方法：采用C57BL/6小鼠以及Sig-1受体基因敲除小鼠双侧颈总动脉(BCCAO) 20分钟制作脑缺血再灌注模型.Sig-1R激动剂PRE084及NR2A受体拮抗剂PEAQX每日给予一
Alzheimers disease (AD), a neurodegenerative disease,is seriously threatening the health of the elderly.In recent years,exercise is accepted as a kind of physical fitness.It is reported that moderate
目的:阿尔茨海默病(Alzheimers disease,AD)是一种与衰老相关的慢性中枢神经系统退行性疾病,其发病机制至今未被阐释清楚.近年来临床研究发现,脑能量代谢障碍是AD病程中出现最早的病理改变之一.AD患者在记忆障碍出现之前,即可在后扣带回、顶颞叶皮层、海马等多个与记忆认知相关的脑区检测到能量代谢水平的降低.另外,对轻度认知障碍(mild cognitive impairment,MCI