【摘 要】
：
目的：机械通气(MV)在临床应用愈加重要,已经成为临床救治急重症患者必不可少的治疗手段之一。然而,机械通气对患者呼吸系统乃至全身生理产生的影响也逐渐引起临床医生越来越多的关注。机械通气所致肺损伤(ventilator-induced lung injury,VILI)是最常见并发症之一,相关临床表现为肺间质水肿、纵隔气肿、气胸、空气栓塞等。其可能发生机制研究甚广,包括通气过程中形成的容积伤和气压伤
【机 构】
：
烟台市毓璜顶医院 山东大学齐鲁医院
【出 处】
：
中国中西医结合麻醉学会年会暨第二届全国中西医结合麻醉学术研讨会
论文部分内容阅读
目的：机械通气(MV)在临床应用愈加重要,已经成为临床救治急重症患者必不可少的治疗手段之一。然而,机械通气对患者呼吸系统乃至全身生理产生的影响也逐渐引起临床医生越来越多的关注。机械通气所致肺损伤(ventilator-induced lung injury,VILI)是最常见并发症之一,相关临床表现为肺间质水肿、纵隔气肿、气胸、空气栓塞等。其可能发生机制研究甚广,包括通气过程中形成的容积伤和气压伤等机械性损伤,促炎介质释放与抗炎介质失衡、氧化与抗氧化平衡状态的破坏、细胞表面分子构象改变、细胞骨架重塑等生物性损伤。随着机械通气所致肺损伤(VILI)发病机制逐步前面、深入的研究,人们对采取一些列预防和治疗措施,包括保护性通气策略、抗炎药物的应用、抗氧化治疗等机械通气介导的肺损伤主要的病理生理表现为炎性反应和炎性细胞浸润。研究表明抗CD11c抗体依法朱单抗具有抑制T细胞活化,转移和角蛋白细胞的粘附,从而抑制机械通气肺损伤炎性反应,我们设想其具有机械通气肺损伤保护作用。
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