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Prostate specific membrane antigen (PSMA) is overexpressed on prostate tumor cells and the neovascular endothelia various solid tumors.A bivalent immunotoxin generated by fusing a fold-back single-chain diabody derived from the Fv fragments of an anti-PSMA monoclonal antibody with a truncated diphtheria toxin (DT)containing the activity and translocation domains [A-dmDT390-scfbDb (PSMA)] might be suitable for targeted therapy of tumors that overexpress PSMA.