An Anti-PSMA Bivalent Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Imaging and

来源 :International Conference on Nanoscience & Technology,China 2 | 被引量 : 0次 | 上传用户：cdelphiboy

【摘要】

：

【作者】

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Fayun Zhang Rajagopalan Sridhar Wei Liang Paul Wang Liang Shan Yuanyi Liu David Neville Jung-Hee Woo Yue Chen Alexandru Korotcov Stephen Lin Sophia Huang

【机构】

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Molecular Imaging laboratory,Howard University,Washington,DC 20060,USA;Protein and Peptide Pharmaceu

【出处】

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International Conference on Nanoscience & Technology,China 2

【发表日期】

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2013年3期

【关键词】

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diphtheria toxin DT390 immunotoxin prostate-specific membrane antigen targeted d

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　　Prostate specific membrane antigen (PSMA) is overexpressed on prostate tumor cells and the neovascular endothelia various solid tumors.A bivalent immunotoxin generated by fusing a fold-back single-chain diabody derived from the Fv fragments of an anti-PSMA monoclonal antibody with a truncated diphtheria toxin (DT)containing the activity and translocation domains [A-dmDT390-scfbDb (PSMA)] might be suitable for targeted therapy of tumors that overexpress PSMA.

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An Anti-PSMA Bivalent Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Imaging and

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