Objective: To discuss the technical points and the short-term curative effect of bore puncture for the treatment of L5/S1 intervertebral disc herniation with transiliac approach intervertebral en-doscopic discectomy.Method: Nineteen patients from March 2014 to September 2015 were diagnosed as L5/S1 disc herniation,and accepted nucleus pulposus excision treatment through approach endoscop-ic discectomy (transiliac approach group,group Ⅰ).At same times,20 patients were diagnosed as non-L5/S1 disc herniation,and underwent conventional approach endoscopic discectomy (conven-tional approach group,group R).The operation time and intraoperative fluoroscopy times of the two groups were analyzed and compared.The leg pain was evaluated by visual analogue scale (VAS)at preoperatively,immediately postoperatively and 12 months postoperatively,respectively.Mac-Nab Ratings of last follow-up were recorded to evaluate early clinical efficacy,and postoperative complications were recorded to evaluate surgical safety.The imaging changes of the patients with 3 months after surgery were observed.Result: One case in group Ⅰ who felt abnormal in nerve root exit zone took dehydration,hor-mone and other symptomatic treatment,and the abnormalities disappeared 3 days after treatment.There were no obvious complications in the rest patients,and all patients received outpatient fol-lowed up for 12 months.There were no obvious statistical significance in operative time and intra-operative fluoroscopy times between group Ⅰ and R (p > 0.05),but group Ⅰ had a higher tendency.The VAS scores of post-operation were significantly lower than pre-operation in the two groups (p <0.05),but the difference between groups were not statistically significant (p > 0.05).The MacNab score of the last follow-up showed excellent and good rate of 94.7% (18/19) and 90% (18/20) in group Ⅰ and group R,respectively.Conclusion: Bone puncture combined transiliac approach intervertebral endoscopic surgery could locate iliac puncture point individually,and this contributed to establish a good iliac channel.The therapy of L5/S1 disc herniation is a safe,effective,and minimally invasive treatment.