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目的:观察健脑安神胶囊对失眠大鼠睡眠时相及肝、肾功能的影响。方法:将80只Wister大鼠,随机分为假手术组、模型组、中药模型治疗组、西药模型治疗组各20只,采用对氯苯丙氨酸(PCPA)腹腔注射复制失眠大鼠模型,各组灌胃治疗3周,治疗前后监测各组大鼠脑电图(EEG)、眼动电图(EOG)、肌电图(EMG)及肝、肾功能的变化。结果:中药模型治疗组与模型组相比觉醒期(Waking)明显缩短,慢波睡眠期(SWS)、快动眼睡眠(REMS)、总睡眠期(TST)明显回升(P<0.01)。比较4组治疗前后尿素氮、肌酐、谷丙转氨酶、谷草转氨酶,无统计学意义(P>0.05)。结论:健脑安神胶囊治疗失眠的疗效确切,其治疗失眠的作用机制与减少失眠大鼠的觉醒时间,延长SWS、REMS、TST期有关。且该药物对大鼠肝肾功能无明显损害,具有良好的药物安全性。
Objective: To observe the effect of “Jiannao Anshen Capsule” on sleep phase, liver and kidney function in insomnia rats. Methods: Totally 80 Wister rats were randomly divided into sham operation group, model group, TCM model treatment group and western medicine treatment group, 20 rats in each group. The model of insomnia was induced by intraperitoneal injection of PCPA, The rats in each group were given gavage for 3 weeks. EEG, EOG, EMG, liver and kidney function were monitored before and after treatment. Results: Compared with the model group, Waking group significantly shortened WTS, SWS, REMS and TST increased significantly (P <0.01). Comparing the four groups before and after treatment of urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, no statistically significant (P> 0.05). Conclusion: Jiannaoshen Capsule is effective in treating insomnia. Its mechanism of treating insomnia is related to reducing wakefulness, prolonging SWS, REMS and TST in insomnia rats. And the drug has no obvious damage to rat’s liver and kidney function, has good drug safety.