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Object Schizophrenia is characterized by various behavioral abnormalities including cognitive dysfunction.Neonatal ventral hippocampus (NVH)-lesioned rats show schizophrenia-like behaviors including cognitive impairment (1).We recently developed a novel cognitive enhancer,ST101,which is under investigation of clinical trial Phase Ⅱ (2).Here,we define the mechanism underlying cognitive impairment of NVH-lesioned rats and test whether ST101 improve cognitive impairment observed in NVH-lesioned rats.