2. 您的位置
3. 首页
4. 会议论文
5. A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：dv_lover

【摘 要】

：

The HECT type E3 ligases are key regulators of cell growth and proliferation,and malfunctions of these enzymes are associated with a broad range of human tumors and other diseases.

【作 者】

：

Zhen Wang Ziheng Liu Kang Zhu Zelin Shan Weiyi Yao Xing Chen Jingyu Li Shijing Huang Aihong Gu Wenyu Wen 

【机 构】

：

Institutes of Biomedical Sciences,Shanghai Medical College,Fudan University,Shanghai 200032

【出 处】

：

中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

：

2019年10期

【关键词】

：

Nedd4 family E3 ligases HECT ubiquitination allosteric regulation cell migration 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The HECT type E3 ligases are key regulators of cell growth and proliferation,and malfunctions of these enzymes are associated with a broad range of human tumors and other diseases.

其他文献

The saponin D39 blocks dissociation of nonmuscular myosin heavy chain IIA from TNF receptor 2,suppre

Non-muscular myosin heavy chain IIA(NMMHC IIA)plays a key role in tissue factor expression and venous thrombosis.Natural products might inhibit thrombosis through effects on NMMHC IIA.

会议

nonmuscular myosin heavy chain IIATNF receptor 2saponin D39tissue factorveno

The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin

Anthrax lethal toxin(LT)is known to induce NLRP1B inflammasome activation and pyroptotic cell death in macrophages from certain mouse strains in its metalloprotease activity-dependent manner,but the u

会议

Anthrax lethal toxinN-end rule pathwayNLRP1B inflammasomeUBR2

An insight into the biological function of a highly conserved C-terminal domain of Indian hedgehog N

Indian hedgehog(Ihh)is a highly conserved secreted signaling protein involved in regulating cartilage formation and development.

会议

Indian hedgehog signaling pathwayC-terminus of IhhNBiological functionSelf cl

TCAB1 induces Epithelial-to-mesenchymal transition by recruiting USP11 deubiquitized TGFβR2 to activ

TCAB1(Telomere Cajal Body protein 1)is an important component of Cajal body.It participates in telomere elongation,repairs DNA double strands break and promotes tumor development.

会议

TCAB1USP11TGFβRⅡEMT

SIRT6 Inhibitor,OSS_128167 Restricts HBV Transcription and Replication through Targeting Transcripti

Hepatitis B virus(HBV)is a major public health threat and leading to end-stage liver diseases,such as hepatitis and hepatocellular carcinoma.

会议

OSS_128167SIRT6HBVantiviralcore promoterPPARα

REGγ Ablation Impedes Dedifferentiation of Anaplastic Thyroid Carcinoma and Accentuates Radio-therap

Anaplastic thyroid cancer(ATC)is the most aggressive human thyroid malignancy,characterized by dedifferentiation and resistance to radioiodine therapy.

会议

REGγanaplastic thyroid cancerNISradioiodine therapyTGF-βSmad7

Molecular Mechanisms and Therapy Strategies of AGR2 induced Chemoresistance

Malignant tumors are serious diseases that seriously threaten human health.The treatment is mainly based on surgical treatment,radiation therapy,chemotherapy and immunotherapy in recent years.

会议

AGR2disulfide isomerasemultidrug resistanceangiogenesisproteasome activity

CRISPR/Cas9-mediated gene knockout for DNA methyltransferase Dnmt3a in CHO cells displays enhanced t

DNA methyltransferase Dnmt3a was knocked out by CRISPR/Cas9 technology to construct Dnmt3a-deficient CHO cell expression system.

会议

Chinese hamster ovary cellDNA methylationDNA methyltransferase Dnmt3agene kno

hCINAP regulates the DNA damage response and mediates the resistance of acute myelocytic leukemia ce

Maintenance of genomic stability is critical for the proper function of organisms.When DNA damage occurs and is detected,a series of repair proteins sequentially accumulate at the damaged site and ind

会议

hCINAPNPM1double-stranded DNA breaks (DSB)SUMOylationacute myeloid leukemia

Design and Preliminary Activity Determination of anti-tumor peptides targeting integrin αvβ3

Objective Design a couple of RGD loop-containing peptides on the basis of the structure of echistatin and evaluate the preliminary activity.

会议

Integrin αvβ3RGD loopEchistatinColorectal cancer