【摘 要】
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Elevated plasma triglyceride (TG) level had been established as an independent risk factor of developing multiple cardiovascular diseases.It is of clinical importance to identify genetic determinants
【机 构】
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Department of Laboratory Medicine,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,S
【出 处】
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中华医学会第八次全国中青年检验医学学术会议
论文部分内容阅读
Elevated plasma triglyceride (TG) level had been established as an independent risk factor of developing multiple cardiovascular diseases.It is of clinical importance to identify genetic determinants of plasma TG levels.11q23.3-q23 gene cluster,including APOA1,APOC3,APOA4 and APOA5 blood lipid gene,is the top hit of the significantly associated loci,and accounts for the greatest genetic effect on TG variance.APOA5 promotes lipoprotein lipase mediated plasma TG hydrolysis.
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