【摘 要】
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Prostate cancer (PCa) is one of the most common malignancies in the world.Prostate specific antigen (PSA) is widely accepted as a serum biomarker for the diagnosis of PCa.However, due to its low speci
【机 构】
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Department of Urology,Kyoto University Graduate School of Medicine
【出 处】
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第十三届亚洲泌尿外科学会年会(UAA2015)、第二十二届全国泌尿外科学术会议(CUA2015)、第十六届全军及武警泌尿
论文部分内容阅读
Prostate cancer (PCa) is one of the most common malignancies in the world.Prostate specific antigen (PSA) is widely accepted as a serum biomarker for the diagnosis of PCa.However, due to its low specificity and lack of relevance with aggressiveness, novel biomarkers to complement PSA are needed.We have focused on urine samples voided after digital rectal examination (DRE), which could be expected to contain many peptides and protein-fragments secreted from prostatic microenvironments,enabling detection of secreted prostate products as potential sources of PCa specific biomarkers.Therefore, we conducted peptidomic and proteomic analyses of the urine samples voided after DRE.
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