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Background and objective: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liverdiseases and affects more than one-third of thepopulation in the world.Innate immune cells are likely to play a pivotalrole in responding to inflammation and metabolic stresses by orchestrating local immune responses through thesecretion of cytokines and chemokines.IL-33,a member of the IL-1 family,can act on immune cells.