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Objective Glucocorticoids are administered in moderate and severe cases of subacute thyroiditis (SAT),providing markedly relief from fever and pain.To our knowlage, there have been no reports regarding the efficiency using short-term prednisone course to treat SAT.In our study, we used 30mg/d of prednisone as the initial dosage only one week and NSAIDs following up next week.We assessed the efficiency and safety of this treatment protocol.Methods This is a prospective, randomized, controlled, single-blind study.(ClinicalTrials.gov ID: NCT01837433).We examined 36 patients with moderate and severe SAT who visited our thyroid clinic between August 2013 and April 2014.They were randomly divided into two groups.In experimental group,we used prednisone 30mg/d as the initial dosage one week and celecoxib 400mg in first day, and then 200mg bid in the remaining next week, total 2 weeks.