【摘 要】
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Osthole is one of the major components ofCnidium monnieri (L.) Cuss with the structure of an isopentenoxy-coumarin [1].It has been used in the treatment of skin disease and gynecopathy [2].In recent y
【机 构】
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College of Pharmacy; Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University; D
【出 处】
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第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议
论文部分内容阅读
Osthole is one of the major components ofCnidium monnieri (L.) Cuss with the structure of an isopentenoxy-coumarin [1].It has been used in the treatment of skin disease and gynecopathy [2].In recent years, its diverse pharmacological activities, such as anti-oxidant, antitumor, and estrogen-like effects, were reported.In present paper, the metabolism of osthole in rats was investigated by identifing metabolites excreted into urine.Ten phase I metabolites ofosthole were isolated from the urine of rats after an oral dose of 40 mg/kg, and their real structures were identified on the basis of wide spectroscopic data including 2D-NMR technologies.
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