【摘 要】
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Analysis of VH and VL sequences of conventional antibodies from camelids reveals a surprising high degree of sequence homology with human segments.In silico prediction suggests identical canonical fol
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Analysis of VH and VL sequences of conventional antibodies from camelids reveals a surprising high degree of sequence homology with human segments.In silico prediction suggests identical canonical folds of the CDRs and combinations as found in matching human germline V regions, thus yielding binding site structures identical as those occurring in human antibodies.This finding encouraged us to explore the possible application of camelid derived antibodies for therapy.
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