稀有鮈鲫fundc1的表达和功能研究

来源 :第三届全国发育生物学大会 | 被引量 : 0次 | 上传用户：my525

【摘要】

：

　　Fundc1是新近发现的线粒体自噬发生的受体之一.我们以稀有鮈鲫为实验材料，研究了Funde1的表达特征和相关功能.qRT-PCR表明Fundc1是母源基因，在胚胎发育初期呈现动态表达，囊

【作者】

：

徐功玉常培郭毛毛张润帅周青春钟雪萍赵浩斌

【机构】

：

华中师范大学生命科学学院,湖北省遗传调控和整合生物学重点实验室,武汉430079

【出处】

：

第三届全国发育生物学大会

【发表日期】

：

2016年10期

【关键词】

：

Fundc1 稀有鮈鲫胚胎发育表达低氧诱导

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论文部分内容阅读

　　Fundc1是新近发现的线粒体自噬发生的受体之一.我们以稀有鮈鲫为实验材料，研究了Funde1的表达特征和相关功能.qRT-PCR表明Fundc1是母源基因，在胚胎发育初期呈现动态表达，囊胚期表达量最高，随后呈降低趋势，直至胚胎出苗降至最低水平；原位杂交(WISH)结果证实Fundc1在囊胚期信号较强，呈全身性表达，信号主要集中在头部和脊索.Fundc1在成鱼脑、心脏和卵巢等高耗能组织呈高水平表达.低剂量Fundc 1-mRNA-GFP超表达仅仅延迟胚胎出苗并不对胚体造成损伤，其荧光信号可追踪至胚胎后脑、头部、脊索、体节.

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稀有鮈鲫fundc1的表达和功能研究

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