Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease

来源 :中国长江医学论坛——2014呼吸病学年会暨江苏省第二十次呼吸病学学术会议 | 被引量 : 0次 | 上传用户:DK3884123
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Newcastle disease virus(NDV) is a member of genus Avulavirus in the Paramyxoviridae family and its antitumor property depends on the ability to kill malignant cell while leaving normal cells.We investigated a recombinant avirulent NDV LaSota strain expressing the rabies virus glycoprotein(RVG) namely rL-RVGs expression and its oncolytic effect on lung adenocarcinoma AS49 cell line and evaluated its potential to serve as a vaccine against lung cancer.
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