【摘 要】
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The catalytic enantioselective construction of tertiary alcohols is a challenging research topic in organic chemistry, as chiral tertiary alcohols are ubiquitous motifs in the pharmaceutical industry,
【机 构】
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Department of Chemistry, Tianjin University, Tianjin 300072, China
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The catalytic enantioselective construction of tertiary alcohols is a challenging research topic in organic chemistry, as chiral tertiary alcohols are ubiquitous motifs in the pharmaceutical industry, biological sciences, as well as versatile intermediates in organic synthesis.[1] The asymmetric decarboxylative aldol reaction,[2] broadly utilized for the generation of enolate equivalents by extruding CO2 from carboxylic acids, has become an attractive method to access chiral alcohols.Recently,β-ketoacids have become an attractive synthon in enantioselective decarboxylative transformation.
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