Objective The hemodynamic mechanism of Budd-Chiari syndrome (BCS) is the research hotspot in recent years. To apply computational fluid dynamics (CFD) methods based on Budd-Chiari syndrome with inferior vena cava stenosis for 3-d numerical simulation and discuss the hemodynamic characteristics. Methods 3D model was established from a patient with Budd-Chiari syndrome through MR, and then it was underwent numerical simulation with Ansys. Results Vortex in the narrow area above can be found in the streamline figures, throughout the coronal section graph, blood flow velocity achieved maximum in the center of the stenosis, the static pressure value gradually declined at the narrow area entrance to the narrowest place, and achieved minimum value at the exit; the maximum wall shear stress existed in the stenosis. Conclusion Patient-specific 3D computational fluid dynamic model of Budd-Chiari syndrome with inferior vena cava stenosis can show the hemodynamic validly, hemodynamic parameters could be used for clinical practice and get further study on the correlation of complex hemodynamic parameters and morphology changes of inferior vena cava vascular.