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The β‐secretase,β‐site amyloid precursor protein(APP)cleaving enzyme 1(BACE1),is the first of two proteases(the second being γ‐secretase)to cut APP to generate the β‐amyloid peptide(Aβ)implicated in Alzheimers disease(AD)pathogenesis.As such,BACE1 is a prime therapeutic target for lowering cerebral Aβ levels as a treatment strategy for AD.